The Indiana Institute for Biomedical Imaging Sciences has been created to foster the development, testing, and translation of modern biomedical imaging technologies and methodologies into clinical care in order to advance our ability to care for patients. Through the many pages of our web site you can learn about the exciting research being performed by our scientific members. You will also find links to educational information for both the public and research scientists. I would like to thank you for visiting our web site and hope that you find the information and contact links helpful as you explore the capabilities and opportunities of modern biomedical imaging.
Dr. Liang's research interest is to develop imaging techniques for biomedical studies using X-ray computed tomography (CT). Currently she is working on (1) methodology design for quantifying tissue physiology and evaluation of the methods with other references; (2) instrumentation development for new generation of microCT and its integration with photo-acoustic CT to achieve the combined capability of high-resolution structural and molecular imaging in small animals.
Graduate: State University of New York at Stony Brook, USA
Doctorate:State University of New York at Stony Brook, USA
Postdoctoral Fellowship: Argonne National Laboratory, USA
Postdoctoral Fellowship: Department of Radiology, Indiana University, Indianapolis, IN
- Liang Y and RA Kruger, "Dual-slice Spiral versus Single-slice Spiral Scanning: Comparison of the Physical performance of Two Computed Tomography Scanners." Med Phys 24(2): 205-220, 1996.
- Liang Y and RA Kruger, "Response to modulation transfer functions of single-slice and dual-slice computed tomography scanners." Med Phys 23(11): 1865, 1996
- Wei J, Sandison GA, Chen L, Liang Y, Xu L, " X-ray CT high density artifact suppression in cryosurgery ", Physics In Medicine and Biology, 47:N319-N326, 2002.
- Liang, Y. Stantz, K. M. Krishnamurthi, G. Chen, L. Hutchins, G. D., "Investigation of Contrast-Enhanced In-Vivo Animal Imaging With Micro-CT". IMECE, VOL 54, pages 139-144, 2002
- Chen L, Liang Y, Heuscher DJ, "General Surface Reconstruction of Cone-beam Multi-slice CT". Med. Phys. 30 (10): 2804-2821, 2003
- Liang Y, Stantz KM, Krishnamurthi G, Steinmetz R, Hutchins GD, " Development of contrast-enhanced rodent imaging using functional CT." Proc. SPIE Vol. 5031, P. 140-148, 2003.
- Rydberg J, Liang Y, Teague SD, Fundamentals of multichannel CT, Radio Clin N Am 41 465-474. 2003
- Krishnamurthi G, Stantz KM, Steinmetz R, Gattone VH, Hutchins GD, Liang Y, Functional imaging in small animals using X-ray computed tomography. IEEE Trans. Med. Imaging, p.832-843, 2005.
- Stantz KM, Liu B, Cao Minsong, Reinecke D, Dzemidzic M, Liang Y, Kruger R. "Evaluating Dynamic Contrast-Enhanced and Photoacoustic CT to Assess Intra-Tumor Heterogeneity in Xenograft Mouse Models", Proc. SPIE Vol. 6143:489-500, (2006).
Scientific Reviewer, National Institute of Health
Session chair, SPIE (The International Society for Optical Imaging) Meetings
2001 - 2004 Whitaker Foundation (PI: Liang), "Ungated Cardiac Imaging with Subsecond Multi-slice Spiral CT."
2005 - 2006 Whitaker Foundation (PI: Liang), "Feasibility Evaluation of Functional MicroCT for Tumor Physiology in Rodents."
2004 NIH SBIR (Subcontract PI: Liang), "Development of functional microCT applications for rodents." 5R44CA001807-03
Last update: 9/12/2007
Definition: Spectroscopy is the use of light, sound or particle emission to study matter. The emissions are, in many cases, able to provide information about the properties of the matter under investigation. The device often used for such analysis is a spectrometer, which records the spectrum of light emitted (or absorbed) by a given material, especially in analytical chemistry and physical chemistry fields, where the light can be used to determine the chemical composition of a substance because of signature spectral lines emitted by known elements.
Similar devices, called spectrographs, are frequently incorporated into major telescopes, and can similarly be used to identify the composition of stars and other astronomical bodies, based on the light they emit.
Dr. Dydak’s research focuses on the development and optimization of fast and high resolution spectroscopic imaging (MRSI). Such techniques allow mapping the spatial and temporal distribution of metabolite concentrations under normal and pathological conditions in patient friendly scan times. Applications range from diagnosing metabolic diseases to monitoring treatment responses or studying the biochemical changes underlying a disease or disorder. While 1H MRS is most commonly used due to its high sensitivity, Dr. Dydak’s team is also engaged in developing and optimizing techniques for spectroscopy and imaging of other nuclei such as 31P and 23Na, which are equally of high interest for clinical application.
Over the past several years, the incorporation of physiologic based imaging techniques into numerous research programs has occurred through collaborations fostered by Dr. Hutchins. This has played an integral role in the development of research programs at IU. Dr. Hutchins has served on numerous scientific review study sections including multiple NIH programs, the Department of Energy and the Canadian Foundation for Innovation.
|Pre-clinical Directors and Faculty|
|Vice Chairman for Research
John W. Beeler Professor of Radiology
|Paul Territo, Ph.D.||Associate Research Professor|
| Chen Lin, Ph.D.
||Clinical Assistant; Professor, MRI Physicist|
|Yun Liang, Ph.D.
||Associate Professor, Medical Physicist|
|Keith Stantz, Ph.D.
||Adjunct Assistant Professor, Radiology|
|Karmen Yoder, Ph.D.||Assistant Professor of Radiology|