Mark A. Green Ph.D.
Professor Green serves as the Director of Radiopharmaceutical Sciences for the Indiana Institute for Biomedical Imaging Sciences (IIBIS) in the Department of Radiology and Imaging Sciences. To support basic and clinical research investigations employing positron emission tomography (PET), his group operates an 11-MeV cyclotron for the routine production of short-lived PET radiopharmaceuticals. Associated research infrastructure includes 19 Comecer hot cells; multiple automated radiochemical synthesis systems for preparation of oxygen-15, nitrogen-13, carbon-11, and fluorine-18 radiopharmaceuticals; and a pneumatic tube system for rapid radiopharmaceutical transport to our multiple PET camera sites.
Professor Green’s research focus is the design, synthesis, evaluation, and validation of new radiopharmaceutical agents. The practice of nuclear medicine is based on imaging the internal distribution and pharmacokinetics of such radioactive drugs, drugs that selectively and specifically probe clinically relevant aspects of regional tissue function (normal vs. pathophysiology). Radiochemically, his research is primarily exploring applications for short-lived metallic radionuclides (e.g., copper-62, copper-64, gallium-68); nuclides selected for investigation because they offer unique and/or attractive nuclear and chemical properties. Current research interests include: development of tracers for the study of regional tissue perfusion (cerebral, myocardial, renal, and tumor blood flow); strategies for selective radiotracer targeting to neoplastic tissue; and general biomedical applications of radiotracer methods.
B.S. Rose-Hulman Institute of Technology (Chemistry) 1978
Ph.D. Indiana University (Inorganic Chemistry) 1982
Postdoctoral Department of Radiology, Washington University School of Medicine 1982-85
1. [62Cu]-Labeled Pyruvaldehyde Bis(N4-methylthiosemicarbazonato)copper(II): Synthesis and Evaluation as a Positron Emission Tomography Tracer for Cerebral and Myocardial Perfusion, J. Nucl. Med., 31, 1989-1996, 1990. M.A. Green, C.J. Mathias, M.J. Welch, F. Fernandez-Rubio, J.S. Perlmutter, M.E. Raichle, and S.R. Bergmann. PMID: 2266398.
2. Quantification of Regional Myocardial Perfusion with Generator-Produced Copper-62-PTSM and Positron Emission Tomography. Circulation, 87, 173-183, 1993. P. Herrero, J. Markham, C.J. Weinheimer, C.J. Anderson, M.J. Welch, M.A. Green, and S.R. Bergmann. PMID: 8419005.
3. Evaluation of Cu-PTSM as a Tracer of Tumor Perfusion: Comparison with Labeled Microspheres in Spontaneous Canine Neoplasms. Nucl. Med. Biol., 21, 83 - 87, 1994. C. J. Mathias, M. A. Green, W. B. Morrison, and D. W. Knapp.
4. Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo, Chemistry and Biology, 7:335-343; 2000. V. Sharma, A. Beatty, S.P. Wey, L. Bass, C.L. Crankshaw, M.A. Green, M.J. Welch, and D. Piwnica-Worms. PMID: 10801474.
5. Evaluation of 111In-DTPA-Folate as a Receptor-Targeted Diagnostic Agent for Ovarian Cancer: Initial Clinical Results, Journal of Nuclear Medicine, 44;700-707; 2003. B.A. Siegel, F. Dehdashti, D.A. Mutch, D.A. Podoloff, R. Wendt, G.P. Sutton, R.W. Burt, R. Ellis, C.J. Mathias, M.A. Green, D.M. Gershenson. PMID: 12732670.
6. Targeting the Tumor-Associated Folate Receptor with a 111In-DTPA Conjugate of Pteroic Acid. J. Am. Chem. Soc., 2005, 127:7421-7426. C.Y. Ke, C.J. Mathias, and M.A. Green. PMID: 15898791.
7. Assessment of Cu-ETS as a PET Radiopharmaceutical for Evaluation of Regional Renal Perfusion. Nucl. Med. Biol. 34:247-255; 2007. M.A. Green, C.J. Mathias, L.R. Willis, R.K. Handa, J.L. Lacy, M.A. Miller, and G.D. Hutchins. PMID: 17383574.
8. Synthesis and Biodistribution of Lipophilic Monocationic Gallium Radiopharmaceuticals Derived from N,N'-bis(3-aminopropyl)-N,N'-dimethylethylenediamine: Potential Agents for PET Myocardial Imaging with 68Ga. Nucl. Med. Biol., 36:39-45; 2009. Yui-May Hsiao, Carla J. Mathias, Shiaw-Pyng Wey, Phillip E. Fanwick, and Mark A. Green. PMCID: PMC2655349.
9. Elucidation of the Human Serum Albumin (HSA) Binding Site for the Cu-PTSM and Cu-ATSM Radiopharmaceuticals, J Pharm Sci., 98:2170-2179; 2009. N.E. Basken, C.J. Mathias, and M.A. Green. PMID: 18937368.
10. Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response. Vaccine 28:3588-3594, 2010. Stephanie M. Noe, Mark A. Green, Harm HogenEsch, Stanley L. Hem.
11. Positron emission tomography (PET) assessment of renal perfusion, Seminars in Nephrology 31:291-299; 2011. Mark A. Green and Gary D. Hutchins.
12. An automated SPE-based high yield synthesis of [11C]acetate and [11C]palmitate: no liquid-liquid extraction, solvent evaporation of distillation required. Nuclear Medicine and Biology 38:1135-1142; 2011. B.H. Mock, C. Brown-Procter, M.A. Green, B. Steele, B.E. Glick-Wilson and Q.H. Zheng.
Positions and Honors
2010- Professor of Radiology and Imaging Sciences, and Director of Radiopharmaceutical Sciences, Department of Radiology, Indiana University School of Medicine, Indianapolis, IN.
1994-2010 Professor, Division of Nuclear Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana.
1990-1994 Associate Professor, Division of Nuclear Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana.
1987-1990 Assistant Professor, Division of Nuclear Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana.
1985-1987 Assistant Professor, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota. Joint appointment, College of Pharmacy, Department of Medicinal Chemistry.
1992 Twelfth Tetalman Memorial Award, The Society of Nuclear Medicine
1986-1991 NIH Research Career Development Award, National Heart, Lung, and Blood Institute