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James W. Fletcher, M.D.

Special Interests: PET/CT Molecular Imaging:
Dr. Fletcher is currently involved in clinical research with a focus on using molecular imaging to characterize the microenvironment of tumors principally by evaluating tumor vasculature, tumor perfusion and the relationship between metabolic activity and blood flow as a measure of tumor resistance or susceptibility to treatment.

Education/Training
St. Louis University School of Medicine, St. Louis, MO
MD, 1968
St. Louis University School of Medicine, St. Louis, MO
Internship, 1968-69
St. Louis University School of Medicine, St. Louis, MO
Resident, 1969-70
St. Louis University School of Medicine, St. Louis, MO
Fellow, 1970-71

Positions and Honors
1971-1972 Clinical Fellow, Radiology, Harvard Medical School, Boston, Massachusetts
1971-1972 Senior Resident, Nuclear Medicine, Peter Bent Brigham Hospital and Children's Hospital Medical Center, Boston, Massachusetts
1972-1975 Assistant Professor of Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri
1976-1983 Associate Professor of Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri
1977-1984 Associate Professor of Radiology, Department of Radiology, Saint Louis University School of Medicine, St. Louis Missouri
1978-1985 Associate Director, Division of Nuclear Medicine, Saint Louis University School of Medicine
1985-1988 Acting Director, Division of Nuclear Medicine, Saint Louis University School of Medicine
1983-present Professor of Medicine, Department of Internal Medicine, Saint Louis University School of Medicine St. Louis, Missouri
1984-present Professor of Radiology, Department of Radiology, St. Louis University School of Medicine, St. Louis, Missouri
1988-2001 Director, Division of Nuclear Medicine, Saint Louis University, St. Louis, Missouri
1990-2001 Director, PET Imaging Center, Saint Louis University, St. Louis, Missouri
2001-present Professor of Radiology, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN
2011-Present Director, Indiana University (IIBIS) Cancer Imaging Center

PubMed

Selected Recent Peer Reviewed Publications:

1. Kymes S, Fletcher JW: Probability and the Principles of Diagnostic Certainty in Medical Imaging Clinical PET-CT in Radiology, Springer, Shreve P, Townsend D. Ed., 2011
2. Kinahan PE, Fletcher JW. Positron Emission Tomography/Computed Tomography Standardized Uptake Values in Clinical Practice and Assessing Response to Therapy. Seminars in Ultrasound CT and MRI. 31(6):496-505, 2010, Dec.
3. Henderson MA, Hoopes DJ, Fletcher JW, Lin PF, Tann M, Yiannoutsos CT, Williams MD, Fakiris AJ, McGarry RC, Timmerman RD. A pilot trial of serial 18F-fluorodeoxyglucose Positron Emission Tomography in patients with medically inoperable stage I non-small-cell lung cancer treated with hypofractionated stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 76(3):789-95, 2010 Mar 1.
4. Kymes SM, Lee K, Fletcher JW; SNAP (CSP 027) Study Group. Assessing diagnostic accuracy and the clinical value of positron emission tomography imaging in patients with solitary pulmonary nodules (SNAP). Clin Trials. 2006;3(1):31-42.
5. Hoopes DJ, Tann M, Fletcher JW, Forquer JA, Lin PF, Lo SS, Timmerman RD, McGarry RC. FDG-PET and stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer. Lung Cancer. 2007 May;56(2):229-34. Epub 2007 Mar 13.
6. Michael K. Gould, James Fletcher, Mark D. Iannettoni, William R. Lynch, David E. Midthun, David P. Naidich, and David E. Ost Evaluation of Patients With Pulmonary Nodules: When Is It Lung Cancer?: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition) Chest Sep 2007: 108S–130. ; DOI 10.1378/chest.07-1353
7. Fletcher JW, Kymes SM, Gould M, Alazraki N, Coleman RE, Lowe VJ, Marn C, Segall G, Thet LA, Lee K; VA SNAP Cooperative Studies Group. A comparison of the diagnostic accuracy of 18F-FDG PET and CT in the characterization of solitary pulmonary nodules. J Nucl Med. 2008 Feb;49(2):179-85. Epub 2008 Jan 16. Erratum in: J Nucl Med. 2008 Mar;49(3):353.
8. Fletcher JW, Djulbegovic B, Soares HP, Siegel BA, Lowe VJ, Lyman GH, Coleman RE, Wahl R, Paschold JC, Avril N, Einhorn LH, Suh WW, Samson D, Delbeke D, Gorman M, Shields AF. Recommendations on the use of 18F-FDG PET in oncology. J Nucl Med. 2008 Mar;49(3):480-508. Epub 2008 Feb 20.
9. Timmerman R. McGarry R. Yiannoutsos C. Papiez L. Tudor K. DeLuca J. Ewing M. Abdulrahman R. DesRosiers C. Williams M. Fletcher J. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. [Clinical Trial, Phase II. Journal Article. Multicenter Study] Journal of Clinical Oncology. 24(30):4833-9, 2006 Oct 20.
10. Fletcher JW: Positron Emission Tomography: Applications in Oncology in Nuclear Medicine. Second Edition, Elsevier, Henkin R, Bova D, Dillehay GL, Karesh SM, Halama JR, Wagner RH, Zimmer AM. Ed. 2006.
11. Conway CR. Sheline YI. Chibnall JT. George MS. Fletcher JW. Mintun MA. Cerebral blood flow changes during vagus nerve stimulation for depression. [Psychiatry Research. 146(2):179-84, 2006 Mar 31.

James W. Fletcher, M.D.

Professor of Radiology
Chief, Nuclear Medicine
Director, PET Imaging Center
Director, Indiana University (IIBIS) Cancer Imaging Center

Email: James W. Fletcher, M.D.

 

Indiana Institute for Biomedical Imaging Sciences (IIBIS) | Department of Radiology | 950 West Walnut Street, E124 | Indianapolis, IN 46202 | PHONE: (317) 274-2067 | FAX: (317) 274-1067